Epidemiology: Trimodal peak: infancy, puberty, old men.
Site: Retroareolar, usually bilateral.
Microscopic:
Florid to intermediate to fibrous phases Florid: Pseudopapillary hyperplasia (epithelial tufting); myxoid, hypercellular stromal proliferation Fibrous: Periductal fibrosis and epithelial flattening Adjacent PASH can be seen at any stage
Follicular thyroid carcinomas with TERT promoter mutations exhibit a unique global micro-RNA landscape compared to wildtype cases, including miRs that could explain why TERT promoter mutations confer aggressive tumor biology. @EndoPath #pfotd #molpath #thyroidpath