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Dermpedia Consults: Spindle Cell Proliferation With Fat

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Dermpedia Consults: Mesenchymal Neoplasm With Some Features of Cellular Neurothecoma

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Gynecomastia

Etiology: Imbalance of estrogens and androgens.
Epidemiology: Trimodal peak: infancy, puberty, old men.
Site: Retroareolar, usually bilateral.
Microscopic:
Florid to intermediate to fibrous phases
Florid: Pseudopapillary hyperplasia (epithelial tufting); myxoid, hypercellular stromal proliferation
Fibrous: Periductal fibrosis and epithelial flattening
Adjacent PASH can be seen at any stage
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#PFOTD

PATHOLOGY FACT OF THE DAY

Follicular thyroid carcinomas with TERT promoter mutations exhibit a unique global micro-RNA landscape compared to wildtype cases, including miRs that could explain why TERT promoter mutations confer aggressive tumor biology. 
@EndoPath
#pfotd
#molpath #thyroidpath
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